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FULL KARYOTYPE-24 CHROMOSOMES ANALYSIS:
>> CGH
>> Microarray
WHO CAN BENEFIT FROM PGD
Based on our own results, PGD can help the following patients:
Women of 35 and older: Any IVF patient over 35 years of age with more than 5 zygotes and without a history of repeated IVF failure can benefit from PGD (Munné et al. 1999, Human Reprod, 14:2191-2199; Munné et al. 2003 Reprod Biomed Online 7:91-97).
Women with a prior history of repeated spontaneous abortions or trisomic conceptions: Regardless of age, these patients can benefit from PGD with higher implantation rates, reduced spontaneous abortion rates, and reduced risk of chromosomally abnormal conceptions (Munné et al. 2004, Prenat. Diagn 24:638-647).
Carriers of single gene disorders: These patients benefit from PGD by reducing the risk of conceiving an affected baby. Also, through HLA matching, PGD can help select for embryos that are histocompatible with live siblings.
Carriers of chromosome translocations, or other chromosome abnormalities: Translocation carriers can reduce the risk of miscarriage and chromosomally abnormal offspring (Munné et al. 2000, Fertil Steril 73:1209-1218). Other indications: For patients with repeated IVF failure, or extreme male factor, PGD can be useful to find if high rates of chromosome abnormalities are the cause of their infertility.
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WHAT IS REPROGENETICS
Reprogenetics LLC is a genetics laboratory specialized in Preimplantation Genetic Diagnosis (PGD). Although the company was created in 2000, its director, Santiago Munné, and team of scientist have been involved in PGD for more than a decade. These scientists have been involved in PGD since 1991, first providing PGD services at Cornell University, and later at Saint Barnabas Medical Center (Livingston, NJ). They decided to create Reprogenetics as a separate PGD service, offering state-of-the-art genetic testing to reproductive medicine programs for their patients during IVF procedures.
Reprogenetics has two reference laboratories in the U.S.A. where IVF centers can send their samples. One is located on the East Coast in West Orange, NJ; the other on the West Coast in San Francisco, CA.
Overseas in Europe we have a laboratory in Barcelona, Spain: www.reprogeneticsspain.com. And in Asia we have a laboratory in Kobe, Japan: www.reprogenetics.jp
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OUR EXPERIENCE IS SECOND TO NONE
Our personnel have been performing PGD since 1991. We were the first to develop PGD tests for aneuploidy and translocations. The Reprogenetics team members have performed >11,000 PGD cycles.
Reprogenetics has a unique database and analysis methods to track and compare results of PGD patients to untreated patients. In our expert hands, PGD usually increases implantation rates and decreases spontaneous abortion (Munné et al. 1999, Human Reprod, 14:2191-2199; Munné et al. 2003, Reprod Biomed Online, 7:91-97; Munné et al. 2000, Fertil Steril 73:1209-1218).
Reprogenetics is the first and only PGD reference center licensed by the State of New York Department of Health (DOH) to perform PGD for any indication (aneuploidy, translocations, gene defects). The NY DOH is the only agency in the USA regulating PGD as of September 2005.
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THE BEST SERVICE
Reprogenetics serves more than 100 IVF centers in the USA alone, including most of those with the best pregnancy outcomes. For faster analysis we have laboratories on both US coasts: San Francisco, CA (near airport), and West Orange, NJ (near Newark airport). Reprogenetics also has laboratories in Barcelona, Spain and Kobe, Japan.
Embryo biopsy and fixation services:
Reprogenetics offers PGD for all indications, including aneuploidy, translocations, gene defects and HLA matching. Specialists at Reprogenetics train embryologists to perform biopsy and fixation procedures, or alternatively, Reprogenetics can place a trained embryologist in your laboratory within two weeks notice, to perform biopsy and fixation, through our active relationship with IVF Labs, LLC . PGD cases can only be accepted after fixation samples have been evaluated by our laboratory in order to assure the best results. If those samples are not acceptable we retrain embryologists from client centers if needed.
PGD of aneuploidy:
Reprogenetics tests chromosomes X, Y, 13, 15, 16, 17, 18, 21 and 22. This is based on trisomies arriving to term (XY,13,18,21), common in spontaneous abortions (16,22,15,21) and most common aneuploidies found in day 3 embryos (22,16,21,15,17) (Munné et al, Reprod Biomed Online, 2004: 8:81-90).
In addition, for those cells with questionable results, we reanalyze with telomeric probes, which bind to a different locus, and therefore may discriminate probe overlaps or split signals (Colls et al. 2004, Prenat Diagn 24:741-744), thus reducing our error rate to very low levels.
Laboratory time is 6-12 hours after sample arrival; perhaps longer if a third round of telomeric probes is needed.
We can accommodate requests for additional analysis of other chromosomes not involved in the standard test.
For preparing and scheduling a PGD case please follow our "PGD for aneuploidy information pack".
PGD of Translocations:
Reprogenetics scientists have invented and developed most of the PGD approaches to translocations (Munné et al. 1998, Fertil Steril 69:675; Munné et al. 1998; Human Genet, 102:663; Willadsen et al. 1999, Human Reprod 14:470-475; Munné et al. 2000, Fertil Steril. 73:1209; Escudero et al. 2003, Fertil Steril 79: supl 3:1528) and have the widest experience, with over 608 cycles performed to September 15, 2005.
Translocations and other chromosome rearrangements can be diagnosed by PGD using FISH with custom made probe cocktails involving three to four probes. Test with two probes, offered by other centers, may miss some segregation patterns.
Before a PGD cycle can start, blood studies from the carrier as well as extensive preparation of the test is necessary, and therefore these tests should be scheduled well in advance of the IVF procedure. These tests are coordinated through our genetic councilor and a deposit is required.
PGD for translocations can be combined with PGD for aneuploidy, but priority will be given to obtaining translocation results.
PGD for translocations can be combined with PGD for aneuploidy, but priority will be given to obtaining translocation results.
For preparing and scheduling a PGD case please follow our "PGD for translocation information pack".
PGD of Gene Defects:
Reprogenetics offers PGD for any genetic disease with an identified mutation. As for translocations, before a PGD cycle can start, blood studies from both parents as well as extensive preparation of the test is necessary, and therefore these tests should be scheduled in advance of the IVF procedure. These tests are coordinated through our genetic counselor and a deposit is required.
Reprogenetics is the only center licensed to perform this service in the State of New York, the only state regulating PGD to date (sept 15, 2005).
For preparing and scheduling a PGD case please follow our "Information PGD for gene defects".
Genetic Counseling and patient information:
Pursuant to the New York State Civil Rights Law, informed consent is required for the performance of a genetic test for any individual. Genetic counseling of the patient is therefore recommended as part of the informed consent required. Such counseling is best prepared by the genetic counselors associated with the laboratory performing the testing.
Reprogenetics has a staff of genetic consultants and is recommended for every patient undergoing PGD. Such consultation can be done by phone or in person and a letter documenting the counseling will be provided. For further questions or to arrange for consultation, please contact Jill M. Fischer, MS, Director of Clinical Genetic Services of Reprogenetics at (973) 436-5015.
Genetic counseling fees are included in our PGD tests.
In addition to genetic counseling we provide brochures for patients and clinics, with detailed protocols for sample preparation and case coordination, and other information to aid in your discussion with patients, including the latest data which may not yet be published.
We can also link your website to ours (www.reprogenetics.com) for convenience and greater visibility of your center.
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FEES AND METHOD OF PAYMENT:
We have a fee per case, not per embryo. Please see our price list. Reprogenetics prefers to bill the fertility center for PGD services. We can bill your patient directly in advance of the PGD procedure, but this requires that the fertility center provide Reprogenetics with patient contact information.
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TO SET UP AN ACCOUNT:
Please call our Director of Client Services at (973) 436-5012 or email kelly.ketterson@embryos.net.
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07. 05.2007 - World leading PGD experts are issuing a rebuttal to an article on preimplantation genetic diagnosis (PGD)
READ
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07.15, 2007 - A report by Colls et al. of Reprogenetics shows a significant reduction of spontaneous abortions and an increase in pregnancies reaching term after using PGD with "no Result rescue"
READ
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