ADDITIONAL INFORMATION ON PGD:

The following scientific articles are available for extra information about preimplantation genetic diagnosis:

Cohen J, Grifo J (2007) Multicnetre trial of preimplantation genetic screening reported in the New England Journal of Medicine: an in depth look at the findings. Reproductive Biomed Online 15:365-366

Munné S, Gianaroli L, Tur-Kaspa I, Magli C, Sandalinas M, Grifo J, Cram D, Kahraman S, Verlinsky Y, Simpson JL (2007) Sub-standard application of PGS may interfere with its clinical success. Fertil Steril 88:781-784

Colls P, Escudero T, Cekleniak N, Sadowy S, Cohen J, Munne S (2007) increased efficiency of preimplantation genetic diagnosis for infertility using "no result rescue". Fertil Steril. 88:53-61

Steuerwald N, Bermudez M, Wells D, Munne S, Cohen J (2007) Maternal age-related differential global expression profiles observed in human oocytes. Reproductive Biomed. Online 14:700-708

Colls P, Escudero T, Cekleniak N, Sadowy S, Cohen J, Munne S (2007) Increased efficiency of preimplantation genetic diagnosis for infertility using "no result rescue". Fertil Steril. in press

Cohen J, Wells D, Munné S (2007) Removal of two cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests employed to enhance implantation rates. Fertil Steril, 87:496-503

Munné S, Serena C, Colls P, Garrisi J, Zheng X, Cekleniak N, Lenzi M, Hughes P2, Fischer J, Garrisi M, Tomkin G, Cohen J (2007) Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos. Reproductive Biomedicine Online 14:628-634

Otani T, Roche M, Mizuikea M, Colls P, Escudero T, Munné S (2006) Preimplantation genetic diagnosis significantly improves the pregnancy outcome of translocation carriers with a history of recurrent miscarriage and unsuccessful pregnancies. Reproductive Biomed Online 13:869-874

Munné S, Ary J, Zouves C, Escudero T, Barnes F, Cinioglu C, Ary B, Cohen J (2006) Wide range of chromosome abnormalities in the embryos of young egg donors. Reproductive Biomed Online, 12:340-346

Munné S (2006) Chromosome abnormalities and their relationship to morphology and development of human embryos. Reproductive Biomedicine Online 12:234-253

Munné S, Fischer J, Warner A, Chen S, Zouves C, Cohen J, And referring centers PGD group (2006) Preimplantation Genetic Diagnosis Significantly Reduces Pregnancy Loss in Infertile Couples: A Multi-Center Study. Fertil Steril 85:326-332

Munne, S. (2005) Preimplantation genetic diagnosis for chromosome abnormalities. In Jorde, L.B., Little, P.F.R., Dunn, M.J. and Subramaniam, S. (Eds), Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics.  John Wiley & Sons Ltd: Chichester, volume , pp. 176. (60b)

Munné S (2005) Analysis of the segregation of chromosomes during preimplantation genetic diagnosis in both male and female translocation heterozygotes. Cytogenetics and Genomic Res 305-309

Munné S, Velilla E, Colls P, Garcia-Bermudez M, Vemuri MC, Steuerwald N, Garrisi J, Cohen J (2005) Self correction of chromosomally abnormal embryos in culture and implications for stem cell production. Fertil Steril, 84:331-335

Stachecki J, Cohen J, Munne S (2005) Cryopreservation of biopsied cleavage stage biopsied embryos. Reproductive Biomed online 6:711-715

Chen SH, Escudero T, Cekleniak NA, Sable DB, Garrisi MG, Cohen J, Munné S (2005) Maternal balanced translocation is a risk factor for poor response to ovarian stimulation. Fertil Steril 83:1504-1509

Munné S, Chen S, Fischer J, Colls P, Zheng X, Stevens J, Escudero T, Oter M, Schoolcraft W, Simpson JL, Cohen J (2005) Preimplantation genetic diagnosis reduces pregnancy loss in women 35 and older with a history of recurrent miscarriages. Fertil Steril 84:331-335

Gutiérrez-Mateo C, Gadea L, Benet J, Wells D, Munné S, Navarro J (2005) Aneuploidy 12 in a Robertsonian (13;14) carrier: Case Report. Human Reprod 20:1256-1260

Weier HUG, Weier JF, Oter Renom M, Zheng X, Colls P, Nureddin A, Pham CD, Chu LW, Racowsky C, Munné S (2005) Fluorescence in situ hybridization and spectral imaging analysis of human oocytes and first polar bodies. J Histochem Cytochem 53:269-272

Munné S, Escudero T, Fischer J, Chen S, Hill J, Stelling JR, Estop E (2005) Negligible interchromosomal effect in embryos of Robertsonian translocation carriers. Reprod Biomed Online 10:363-369

Munné S, Escudero T, Pere C, Xuezhong Z, Oter M, Garrisi M, Barnes F, Zouves C, Werlin L, Magli C, Cohen J (2004) Predictability of Preimplantation Genetic Diagnosis of Aneuploidy and Translocations on Prospective Attempts. Reprod Biomed Online 9:645-651

Munné S, Sandalinas M, Alikani M, Cohen J (2004) Chromosome abnormalities in human embryos. In: Textbook of Assisted Reproductive Technology. Laboratory and Clinical Perspectives. David K Gardner, Weissman A, Howles CM, Shoham Z, Dunitz M Eds. Chapter 28, 355-377

Munné S, Cohen J (2004) The status of Preimplantation Genetic Diagnosis in Japan: a criticism. Reprod Biomed Online 9:258-259

Stachecki J, Munné S, Cohen J (2004) Spindle organization after cryopreservation of mouse, human, and bovine oocytes. Reprod Biomed Online 8:664-672

Gutiérrez CM, Wells D, Benet J, Sánchez-García JF, Bermúdez MG, Belil I, Egozcue J, Munné S, Navarro J (2004) Reliability of Comparative Genomic Hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes. Human Reprod 19:2118-2125

Gutiérrez-Mateo C, Benet J, Wells D, Colls P, Bermúdez MG, Sánchez-García JF, Egozcue J, Navarro J, Munné S (2004) Aneuploidy study of human oocytes first polar body comparative genomic hybridization and metaphase II fluorescence in situ hybridization analysis. Human Reprod 19:2859-2868

Munné S, Sandalinas M, Magli M, Gianaroli L, Cohen J, Warburton D (2004) Increased rate of aneuploid embryos in young women with previous aneuploid conceptions. Prenat Diagn. 24:638-647

Weier HUG, Weier JF, Oter Renom M, Zheng X, Colls P, Nureddin A, Pham CD, Chu LW, Racowsky C, Munné S (2004) Fluorescence in situ hybridization and spectral image analysis of human oocytes and first polar bodies. J Histochem Cytochem 52:1-4

Colls P, Sandalinas M, Pagidas K, Munné S (2004) PGD analysis for aneuploidy in a patient heterozygous for a polymorphism of chromosome 16 (16qh-). Prenat Diagn 24:741-744

Verlinsky, Y, Cohen J, Munne S, Gianaroli L, Simpson JL, Ferraretti AP, Kuliev A (2004) Over a decade of preimplantation genetic diagnosis experience – a multicenter report . Fertil Steril. 82:292-294

Bermúdez MG, Wells D, Malter H, Munné S, Cohen J, Steuerwald NM (2004) Expression Profiles of Individual Human Oocytes using Microarray Technology. Reproductive Biomedicine Online. Online 8:325-337

Santiago Munné, Muhterem Bahçe, Mireia Sandalinas, Tomás Escudero, Carmen Márquez, Esther Velilla, Pere Colls, Maria Oter, Mina Alikani, Jacques Cohen (2004) Differences in chromosome susceptibility to aneuploidy and survival to first trimester. Reproductive Biomedicine Online, 8:81-90

Munné S (2003) Preimplantation Genetic Diagnosis and Human implantation – A review. Placenta 24: S70-76

Werlin L, Rodi I, DeCherney A, Marello E, Hill D, Munné S (2003) Preimplantation genetic diagnosis (PGD) as both a therapeutic and diagnostic tool in assisted reproductive technology. Fertil Steril, 80 :467-468

Munné S, Sandalinas M, Escudero T, Velilla E, Walmsley R, Sadowy S, Cohen J, Sable D (2003) Improved implantation after preimplantation genetic diagnosis of aneuploidy. Reprod Biomed Online, 7:91-97

Escudero T, Abdelhadi I, Sandalinas M, Munné S (2003) Predictive value of sperm chromosome analysis on the outcome of PGD for translocations. Fertil Steril 79:1528-1534

AbdelhadiI I, Colls P, Sandalinas M, Escudero T, Munné S. Preimplantation genetic diagnosis of numerical abnormalities for 13 chromosomes. Reprod Biomed online, 2003: 6:226-231

Silber S, Escudero T, Lenahan K, Sadowy S, Abdelhadi I, Kilani Z, Munné S (2003) Chromosomal abnormalities in embryos derived from TESE. Fertil Steril, 30-38

Wells D, Escudero T, Levy B, Hirschhorn K, Delhanty JDA, Munné S (2002) First clinical application of comparative genome hybridization (CGH) and polar body testing for Preimplantation genetic diagnosis (PGD) of aneuploidy. Fertil Steril 78, 543-549

Munné S, Cohen J, Sable D (2002) Preimplantation Genetic Diagnosis for advanced maternal age and other indications. Fertil Steril 78:234-236

Munné S, Wells D (2002) Preimplantation genetic diagnosis. Current Opinion Obstet Gynecol 14: 239-244

Velilla E, Escudero T, Munné S (2002)Blastomere fixation techniques and risk of misdiagnosis for PGD of Aneuploidy. Reprod Biomed Online, 4:210-217

Munné S, Sandalinas M, Escudero T, Marquez C, Cohen J (2002)Chromosome mosaicism in cleavage stage human embryos: evidence of a maternal age effect. Reprod Biomed Online 4:223-232

Sandalinas M, Márquez M, Munné S (2002) Spectral karyotyping of unfertilized and non-inseminated oocytes. Molec Human Reprod, 8:580-585

Munné S (2002) Preimplantation genetic diagnosis of numerical and structural chromosome abnormalities. Reprod Biomed Online 4:183-196

Magli MC, Sandalinas M, Escudero T, Morrison L, Ferraretti AP, Gianaroli L, Munné S (2001) Double locus analysis of chromosome 21 for preimplantation genetic diagnosis of aneuploidy. Prenatal diagnosis 21:1080-1085

Munné S (2001) Preimplantation genetic diagnosis of Structural abnormalities. Molec Cell endocrinol 183: S55-S58

Weier HUG, Munné S, Lersch RA, Hsieh HB, Smida J, Chen XN, Korenberg JR, Pedersen RA, Fung J (2001) Towards a full karyotype screening of interphase cells: 'FISH and chip' technology. Molec Cell Endocrinol. 183: S41-S45

Escudero T, Lee M, Stevens J, Sandalinas M, Munné S (2001) Preimplantation Genetic diagnosis of pericentric inversions. Prenatal Diagnosis 21:760-766

Sandalinas M, Sadowy S, Alikani M, Calderon G, Cohen J, Munné S. (2001) Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage. Human Reprod, 16:1954-1958

Obasaju M, Kadam A, Biancardi T, Sultan K, Fateh M, Munné S (2001) Pregnancy rate from the transfer of a single normal embryo in women over 40 years of age undergoing PGD for chromosomal abnormalities. Reproductive Biomedicine Online 2:98-101

Munné S, Escudero T, Sandalinas M, Sable D, Cohen J (2000) Gamete segregation in female carriers of Robertsonian translocations. Cytogenet Cell Genet 90:303-308

Márquez C, Sandalinas M, Bahçe M, Alikani M, Munné S (2000) Chromosome abnormalities in 1255 cleavage-stage human embryos. Reproductive Biomedicine Online 1:17-27

Bahçe M, Escudero T, Sandalinas M, Morrison L, Legator M, Munné S (2000) Improvements of preimplantation diagnosis of aneuploidy by using microwave-hybridization, cell recycling and monocolor labeling of probes. Molec Human Reprod 9:849-854

Munné S, Sepulveda S, Balmaceda J, Fernandez E, Fabres C, Mackenna A, Lopez T, Crosby JA, Zegers-Hochschild F (2000) Selection of the most common chromosome abnormalities in oocytes prior to ICSI. Prerat Diagn 20:582-586

Escudero T, Lee L, Carrel D, Blanco J, Munné S (2000) Analysis Of Chromosome Abnormalities In Sperm And Embryos From Two 45,XY,t(13;14)(q10;q10) Carriers. Prenat Diagn 20:599-602

Munné S, Sandalinas M, Escudero T, Fung J, Gianaroli L, Cohen J (2000) Outcome of preimplantation genetic diagnosis of translocations. Fertil Steril. 73:1209-1218

Lee M, Munné S (2000) Pregnancy after polar body biopsy and freezing and thawing of human embryos. Fertil Steril 73:645-647

Escudero T, Lee Michael L, Sandalinas S, Munné S (2000) Female gamete segregation in two carriers of translocations involving 2q and 14q. Prenat Diagn, 20:235-237

Obasaju M, Kadam A, Sultan K, Fateh M, Munné S (1999) Evidence that sperm quality may adversely affect the chromosome constitution of embryos resulting from ICSI. Fertil. Steril. 1113-1115

Gianaroli L, Magli MC, Ferraretti AP, Munné S (1999) Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with poor prognosis: identification of the categories to which it should be proposed. Fertil. Steril. 72:837-844

Munné S, Magli C, Cohen J, Morton P, Sadowy S, Gianaroli L, Tucker M, Márquez C, Sable D, Ferraretti AP, Massey JB, Scott R (1999) Positive outcome after preimplantation diagnosis of aneuploidy in human embryos. Human Reprod, 14:2191-2199

Gianaroli L, Magli MC, Munné S, Fortini D, Ferraretti AP (1999) Advantages of day four embryo transfer in patients undergoing preimplantation genetic diagnosis of aneuploidy. J. Assisted Reprod Genet 16:170-175

Weier HUG, Munné S, Fung J (1999) patient-specific probes for Preimplantion genetic diagnosis (PGD) of structural and numerical aberrations in interphase cells. J. Assisted Reprod Genet 16:182-191

Bahçe M, Cohen J, Munné S (1999) PGD of aneuploidy: were we looking at the wrong chromosomes? J. Assisted Reprod Genet. 16: 176-181

Magli MC, Gianaroli L, Ferraretti AP, Fortini D, Munné S (1999) Impact of blastomere biopsy and cryopreservation techniques on human embryo viability. Human Reprod. 14:770-773

Willadsen S, Levron J, Munné S, Schimmel T, Márquez C, Scott R, Cohen J (1999) Rapid Visualization of Metaphase Chromosomes in Single Human Blastomeres After Fusion with In Vitro Matured Bovine Eggs. Human Reprod 14:470-475

Munné S and Cohen J (1998) Chromosome abnormalities in human embryos. Human Reprod Update. 4: 842-855

Munné S, Magli C, Bahçe M, Fung J, Legator M, Morrison L, Cohen J, Gianaroli L (1998) Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY, 13, 14, 15, 16, 18, 21, 22. Prenat Diagn. 18:1459-1466

Cohen J, Scott R, Alikani M. Schimmel T, Munné S, Levron J, Wu L, Brenner C, Warner C, Willadsen S (1998) Ooplasmic transfer in mature human oocytes. Molec Human Reprod 4: 269-280

Munné S, Márquez C, Magli C, Morton P, Morrison (1998) Scoring criteria for preimplantation genetic diagnosis of numerical abnormalities for chromosomes X, Y, 13, 16, 18 and 21. Human Molec Reprod 9:863-870

Márquez C, Cohen J, Munné S (1998) Chromosome identification on human oocytes and polar bodies by spectral karyotyping. Cytogenet Cell Genet 81:254-258

Munné S, Fung J, Cassel MJ, Márquez C, Weier HUG (1998) Preimplantation Genetic Analysis of Translocations: Case-Specific Probes for Interphase Cell Analysis. Human Genet, 102:663-674

Magli MC, Gianaroli L, Munné S, Ferraretti AP (1998) Incidence of chromosomal abnormalities from a morphologically normal cohort of embryos in poor-prognosis patients. J Assist Reprod Genet 15:297-301

Munné S, Morrison L, Fung J, Márquez C, Weier U, Bahçe M, Sable D, Grundfelt L, Schoolcraft, Scott R, Cohen J (1998). Spontaneous abortions are reduced after pre-conception diagnosis of translocations. J Assist Reprod Genet 290-296

Munné S, Márquez C, Reing A, Garrisi J, Alikani M (1998) Chromosome abnormalities in embryos obtained following conventional IVF and ICSI. Fertil Steril 69:904-908

Estop AM, Munné S, Cieply KM, Vandermark KK, Lamb AN, Fisch H (1998) Meiotic products of Klinefelter 47,XXY male as determined by sperm fluorescence in-situ hybridization analysis. Human Reprod. 13: 124-127

Munné S, Scott R, Sable D, Cohen J (1998) First pregnancies after pre-conception diagnosis of translocations of maternal origin. Fertil Steril 69:675-681

Gianaroli L, Munné S, Magli MC, Ferraretti AP (1997) Preimplantation genetic diagnosis of aneuploidy and male infertility. Int.J.Androl. 20:Suppl.3:31-34

Gianaroli L, Magli MC, Ferraretti AP, Fiorentino A, garrisi J, Munné S (1997) Preimplantation genetic diagnosis increases the implantation rate in human in vitro fertilization by avoiding the transfer of chromosomally abnormal embryos. Fertil.Steril. 68:1128-1131

Cassel MJ, Munné S, Fung J, Weier HUG (1997) Carrier-specific breakpoint-spanning DNA probes: an approach to preimplantation genetic diagnosis in interphase cells. Human Reprod 2019-2027

Gianaroli L, Magli MC, Munné S, Fiorentino A, Montanaro N, Ferraretti AP (1997) Will preimplantation genetic diagnosis assist patients with a poor prognosis to achieve pregnancy? Hum Reprod 12:1762-1767

Munné S, Magli C, Adler A, Wright G, de Boer K, Mortimer D, Tucker M, Cohen J, Gianaroli L (1997) Treatment-related chromosome abnormalities in human embryos. Human Reprod, 12:780-784

Munné S, Weier, U (1996) Simultaneous enumeration of chromosomes 13, 18, 21, X and Y in interphase cells for preimplantation genetic diagnosis of aneuploidy. Cytogenet. Cell. Genet 75:263-270

Templado C, Marquez C, Munné S, Colls P, Martorell MR, Cieply K, Benet J, Van Kirk V, Navarro J, Estop AM (1996) An analysis of human sperm chromosome aneuploidy. Cytogenet Cell Genet 74:194-200

Dailey T, Dale B, Cohen J and Munné S (1996) Association between non-disjunction and maternal age in meiosis-II human oocytes detected by FISH analysis. Am.J.Hum.Genet, 59:176-184

Kligman I, Benadiva C, Alikani M, Munné S (1996) The presence of multinucleated blastomeres in human embryos correlates with chromosomal abnormalities. Human Reprod, 11:1492-1498.

Benadiva C, Kligman I, Grifo J, Munné S (1996) Aneuploidy 16 in human embryos increases significantly with maternal age. Fertil. Steril. 66:248-255

Munné S, Dailey T, Finkelstein M, Weier HUG (1996) Reduction in signal overlap results in increased FISH efficiency: implications for preimplantation genetic diagnosis. J. Assisted Reprod. Genet. 13:149-156.

Munné S, Alonso ML, Grifo J (1996) case report: unusually high rates of aneuploid embryos in a 28-year old woman with incontinentia pigmenti. Cytogenet. Cell Genet., 72:43-45

Munné S, Alikani M, Tomkin G, Grifo J, Cohen J (1995) Embryo morphology, developmental rates and maternal age are correlated with chromosome abnormalities. Fertil.Steril., 64:382-391

Munné S, Dailey T, Sultan KM, Grifo J, Cohen J.(1995) The use of first polar bodies for preimplantation diagnosis of aneuploidy. Human Reprod. 10:1015-1021

Munné S, Sultan KM, Weier HUG, Grifo J, Cohen J, Rosenwaks Z (1995) Assessment of numerical abnormalities of X, Y, 18 and 16-chromosomes in preimplantation human embryos prior transfer. Am. J. Obs. Gyn 172:1191-1201

Grifo JA, Tang YX, Munné S, Alikani M, Cohen J , Rosenwaks Z (1994) Healthy deliveries from biopsied human embryos. Hum.Reprod. 9:912-916

Palermo G, Munné S and Cohen J (1994) The human zygote inherits its mitotic potential from the male gamete. Hum.Reprod. 9:1220-1225.

Munné S, Weier HUG, Grifo J, Cohen J (1994) Chromosome mosaicism in human embryos.   Biol. Reprod. 51:373-379

Munné S, Grifo J, Cohen J, Weier HUG (1994) Chromosome abnormalities in Arrested Human Preimplantation Embryos: A Multiple Probe Fluorescence In Situ Hybridization (FISH) Study. Am.J.Hum.Genet. 55,1:150-159.

Munné S, Lee A, Rosenwaks Z, Grifo J, Cohen J (1993) diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum Reprod 8:2185-2191