Reprogenetics: Everything associated with PGD: preimplantation genetic diagnosis

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07.15, 2007 - A report by Colls et al. of Reprogenetics shows a significant reduction of spontaneous abortions and an increase in pregnancies reaching term after using PGD with "no Result rescue"
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PGD BREAKING NEWS

2/2006 High rates of chromosome abnormalities are found in embryos from egg donors, suggesting that PGD may be recommended in egg donor cycles.
Embryo chromosome studies show high rates of abnormalities, above 50%, but most embryos studied before this study were from patients 35 and older. | Read

1/2006: PGD significantly reduces the risk of pregnancy loss after IVF
The incidence of miscarriage is correlated with maternal age. The majority of the miscarriages are chromosomally abnormal. | Read

Reprogenetics demonstrates that patients with recurrent pregnancy loss can benefit from PGD
The objective of the study was to determine if Preimplantation Genetic Diagnosis (PGD) and transfer of chromosomally normal embryos would decrease spontaneous abortion rates in patients suffering from recurrent pregnancy loss (RPL). | Read

PGD DIAGNOSIS

Reprogenetics provides PGD analysis to IVF centers, including PGD of aneuploidy for advanced maternal age (such as Down syndrome), repeated IVF failure, recurrent spontaneous abortions, chromosome translocations and inversions, as well as PGD for gene defects such as Cystic fibrosis, fragile X, Myotonic Dystrophy, Thalasaemia, Tay Sachs, and others. We also provide embryologist that can perform embryo biopsy and cell processing.

GENETIC COUNSELING FOR PATIENTS

Patients interested in PGD services could contact an IVF center for which we provide services or directly contact our genetic counselor for an in depth discussion of your case.

ASSOCIATIONS
www.IVFonline.com
www.LifeGlobal.com
www.ivflabs.com

Microarray technology to assess gene expression profiles of human oocytes and embryos.
Introduction: The current knowledge of molecular mechanisms during early development is pretty rudimentary. | Read

Results of PGD for infertility in 3597 cycles
Introduction: Preimplantation genetic Diagnosis of aneuploidy, has been offered clinically since 1993, but it is not until the last few years that through the use of reference PGD laboratories, the technique is available to all USA-based IVFcenters. | Read

Maternal age is the most important parameter predicting aneuploidy yet it is an unpredictable indicator of chromosome abnormalities
Introduction: The increase of aneuploidy with maternal age has been demonstrated both with live birth, fetus, embryos and oocyte data. | Read

The importance of a full chromosome count in PGD
PGD-AS using FISH is limited by the number of chromosomes that can be analysed. | Read

Full Karyotype Interphase Cells Analysis
Early human development depends on the correct temporal and spatial expression of thousands of genes. | Read

Restrictive art laws and PGD
Introduction: It is an irony that in some countries such as Germany and Italy multiple pregnancy and embryo cryopreservation have been artificially diminished by restrictive laws limiting the number of eggs inseminated. | Read

Preimplantation genetic diagnosis (PGD) for chromosome structural aberrations: Outcome and comparison
Introduction: Since 1995, Reprogenetics has performed over 4,500 PGD cycles. | Read

Embryonic chromosome abnormalities
The presence of numerical chromosome abnormalities in human embryos was studied using fluorescence in situ hybridization with up to 9 chromosome specific probes. |Read