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1/2006: PGD significantly reduces the risk of pregnancy loss after IVF

The incidence of miscarriage is correlated with maternal age. The majority of the miscarriages are chromosomally abnormal. The purpose of this study was to determine in a large population of infertility patients (>2000 cycles) if Preimplantation Genetic Diagnosis (PGD) reduced the rate of spontaneous abortions.

Researchers at Reprogenetics, with the collaboration of over 100 IVF clinics performing PGD through Reprogenetics retrospectively compared the spontaneous abortion rate after PGD in those clinics, with that of non-PGD cycles from all IVF cycles (about 400 reporting data).

The study included 2279 cycles of PGD. The pregnancy rate per retrieval was 26.7% (average age 39.6). The mean pregnancy loss for the PGD group (16.7%) was significantly lower (p<0.001) than for the general IVF group (21.5%).   After PGD the spontaneous abortion rate was 14.1% for ages 35-40, and 22.2% for women over 40, compared to 19.4% (p=0.03), and 40.6% (p<0.001) in controls. The frequency of chromosomally abnormal conceptions in first trimester was after PGD (1.2%) was significantly lower (p<0.001) than expected (4.7%).

In conclusion, the data suggests that PGD significantly reduces the risk of spontaneous abortions in women undergoing IVF and PGD, particularly in women over 40. In addition, PGD also may reduce the risk of trisomic offspring.



BREAKING NEWS
High rates of chromosome abnormalities are found in embryos from egg donors, suggesting that PGD may be recommended in egg donor cycles. 2/2006
Embryo chromosome studies show high rates of abnormalities, above 50%, but...| Read
See the abstracts presented by Reprogenetics at the PGDIS meeting (London)
Microarray technology to assess gene expression profiles... | Read
PGD DIAGNOSIS
Reprogenetics provides PGD analysis to IVF centers, including PGD of aneuploidy for advanced maternal age (such as Down syndrome), repeated IVF failure, recurrent spontaneous abortions, chromosome translocations and inversions, as well as PGD for gene defects such as Cystic fibrosis, fragile X, Myotonic Dystrophy, Thalasaemia, Tay Sachs, and others. We also provide embryologist that can perform embryo biopsy and cell processing.  
GENETIC COUNSELING FOR PATIENTS
Patients interested in PGD services could contact an IVF center for which we provide services or directly contact our genetic counselor for an in depth discussion of your case.
ASSOCIATIONS
www.IVFonline.com
www.LifeGlobal.com
www.ivflabs.com

MORE STORIES
Reprogenetics demonstrates that patients with recurrent pregnancy loss can benefit from PGD
The objective of the study was to determine if Preimplantation Genetic Diagnosis (PGD) and transfer of chromosomally normal embryos would decrease spontaneous abortion rates in patients suffering from recurrent pregnancy loss (RPL). | Read
Reprogenetics obtains a license to perform PGD in NY state for any type of PGD
Dear Colleague: In July of 2003, laboratories and assisted reproductive technology (ART) providers were notified that a New York State laboratory permit would be required for facilities performing preimplantation genetic diagnosis (PGD) on single cells derived from embryos by molecular genetic and/or cytogenetic techniques. | Read
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