PREIMPLANTATION GENETIC DIAGNOSIS (PGD) FOR CHROMOSOME STRUCTURAL ABERRATIONS: Outcome and comparison

Fischer, J, Escudero, T, Cinnioglu, C* , Munne, S

Reprogenetics, 101 Old Short Hills Road, Suite 501, West Orange, NJ, 07052, USA

Introduction: Since 1995, Reprogenetics has performed over 4,500 PGD cycles.   The majority of these cycles were performed for PGD for aneuploidy with approximately 10% of these cycles performed for structural chromosome aberrations, primarily translocations.

Materials and Methods: Five hundred twenty-four (524) cycles of PGD for reciprocal translocations, Robertsonian translocations, inversions and deletions were performed.   In these cycles, biopsy and testing was performed on a total of 4,919 embryos and oocytes.

Results: Of the embryos and oocytes tested, 920 (18.7%) were found to be normal/balanced, 785 (15.9%) had other abnormalities and 485 (9.8%) yielded no result.     Of the 524 cycles, 463 had had known outcome data.    The implantation rate was 29.6% with a no transfer rate of 25.7%.   For 3133 cycles of PGD for aneuploidy, the implantation rate was 30.5% with 14.9% of cycles having no transfer.

Conclusions: There is a greater likelihood of undergoing embryo transfer in PGD for aneuploidy cycles in comparison with cycles of PGD for structural aberrations.   However, implantation rates are equivalent for both groups.   PGD for chromosomal structural aberrations can provide comparable and positive outcomes after embryo transfer.